TNFRSF11A antibody (Middle Region)

Catalog No. ABIN5518884

Product Details anti-TNFRSF11A Antibody

Target: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Binding Specificity: AA 235-262, Middle Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFRSF11A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 11A(TNFRSF11A) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequence: YRKKGKALTA NLWHWINEAC GRLSGDKE

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 11A(TNFRSF11A) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Protein Name: Tumor necrosis factor receptor superfamily member 11A

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human RANK (235-262aa YRKKGKALTANLWHWINEACGRLSGDKE), different from the related mouse sequence by seven amino acids.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for TNFRSF11A

Target: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Alternative Name: TNFRSF11A (TNFRSF11A Products)

Synonyms: RANK antibody, RGD1563614 antibody, TNFRSF11A antibody, Ly109 antibody, ODFR antibody, OFE antibody, Rank antibody, TRANCE-R antibody, mRANK antibody, CD265 antibody, FEO antibody, LOH18CR1 antibody, OPTB7 antibody, OSTS antibody, PDB2 antibody, TRANCER antibody, TNF receptor superfamily member 11A antibody, TNF receptor superfamily member 11a antibody, tumor necrosis factor receptor superfamily, member 11a, NFKB activator antibody, Tnfrsf11a antibody, TNFRSF11A antibody

Background: Receptor Activator of Nuclear Factor κ B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling. It is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, this gene is mapped to 18q22.1.

Synonyms: Tumor necrosis factor receptor superfamily member 11A | Osteoclast differentiation factor receptor | ODFR | Receptor activator of NF-KB | CD265 | Tnfrsf11a | Rank | Q9Y6Q6

Gene ID: 8792

UniProt: Q9Y6Q6

Pathways: NF-kappaB Signaling