AMD1 antibody

Catalog No. ABIN5518970

Product Details anti-AMD1 Antibody

Target: AMD1 (Adenosylmethionine Decarboxylase 1 (AMD1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AMD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for AMD1 detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequence: RKNFMKPSHQ GYPHRNFQEE IEFLNA

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for AMD1 detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: adenosylmethionine decarboxylase 1
Protein Name: S-adenosylmethionine decarboxylase proenzyme

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence of human AMD1 (RKNFMKPSHQGYPHRNFQEEIEFLNA).

Isotype: IgG

Application Details

Application Notes: Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for AMD1

Target: AMD1 (Adenosylmethionine Decarboxylase 1 (AMD1))

Alternative Name: AMD1 (AMD1 Products)

Synonyms: ADOMETDC antibody, AMD antibody, SAMDC antibody, Amd1a antibody, Amd1b antibody, AMD1 antibody, AdoMetDC antibody, amd antibody, samdc antibody, fb26e03 antibody, si:ch211-257g8.2 antibody, wu:fb26e03 antibody, zgc:55614 antibody, 1 antibody, Amd-1 antibody, SAMDC 1 antibody, adoMetDC1 antibody, CG5029 antibody, Dmel\\CG5029 antibody, l(2)31Dc antibody, l(2)31Dd antibody, l(2)31De antibody, F16B3.10 antibody, F16B3_10 antibody, S-ADENOSYLMETHIONINE DECARBOXYLASE antibody, S-adenosylmethionine decarboxylase antibody, adenosylmethionine decarboxylase 1 antibody, S-adenosylmethionine decarboxylase 1 antibody, S-adenosyl methionine decarboxylase 2 antibody, adenosylmethionine decarboxylase 1 L homeolog antibody, S-adenosylmethionine decarboxylase antibody, AMD1 antibody, Amd1 antibody, amd1 antibody, sam2 antibody, amd1.L antibody, SamDC antibody, SAMDC antibody

Background: S-adenosylmethionine decarboxylase (AdoMet-DC), also known as S-adenosylmethionine decarboxylase proenzyme (SAMDC) or AMD1, is a key enzyme in polyamine biosynthesis. It is localized to chromosome region 6q21-q22. SAMDC has an unusual distribution in polysomes from cells of T lymphocyte origin. It associates predominantly with monosomes and small polysomes with none located in the preribosomal or ribonucleoprotein pool. SAMDC is a critical regulatory enzyme of the polyamine synthetic pathway, and a well-studied drug target. Since SAMDC is a key regulatory enzyme in the synthesis of spermidine and spermine, the marked increase in SAMDC activity in the neonate and the sustained high enzyme levels throughout adulthood, imply a role for these polyamines in both development and mature brain function.

Synonyms: S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC

Gene ID: 262

UniProt: P17707

Pathways: Ribonucleoside Biosynthetic Process