DPF1 antibody (AA 220-247)

Catalog No. ABIN5530987

Product Details anti-DPF1 Antibody

Target: DPF1 (D4, Zinc and Double PHD Fingers Family 1 (DPF1))

Binding Specificity: AA 220-247

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPF1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DPF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 220-247 amino acids from the Central region of human DPF1.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for DPF1

Target: DPF1 (D4, Zinc and Double PHD Fingers Family 1 (DPF1))

Alternative Name: DPF1 (DPF1 Products)

Synonyms: zgc:110104 antibody, DPF1 antibody, req antibody, xReq antibody, neud4 antibody, requiem antibody, neuro-d4 antibody, BAF45b antibody, NEUD4 antibody, Neud4 antibody, D4, zinc and double PHD fingers family 1 antibody, double PHD fingers 1 antibody, dpf1 antibody, DPF1 antibody, Dpf1 antibody

Background: DPF1 may have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Molecular Weight: 43 kDa

Gene ID: 8193

UniProt: Q92782