KHDRBS1 antibody (AA 259-291)

Catalog No. ABIN5531494

Product Details anti-KHDRBS1 Antibody

Target: KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1))

Binding Specificity: AA 259-291

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KHDRBS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KHDRBS1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 259-291 amino acids from the Central region of human KHDRBS1.

Isotype: Ig Fraction

Application Details

Application Notes: For IHC-P starting dilution is: 1:25

For WB starting dilution is: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.49 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for KHDRBS1

Target: KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1))

Alternative Name: KHDRBS1 (KHDRBS1 Products)

Synonyms: Sam68 antibody, p62 antibody, p68 antibody, fj90g10 antibody, khdrbs1 antibody, wu:fa18g12 antibody, wu:fa56c01 antibody, wu:fc91b01 antibody, wu:fj90g10 antibody, zgc:113899 antibody, KHDRBS1 antibody, P62 antibody, khdrbs1l antibody, sb:cb97 antibody, wu:fb07d11 antibody, wu:fi43c05 antibody, zgc:85948 antibody, KH RNA binding domain containing, signal transduction associated 1 antibody, KH domain containing, RNA binding, signal transduction associated 1a antibody, KH domain containing, RNA binding, signal transduction associated 1 antibody, KH domain containing, RNA binding, signal transduction associated 1 S homeolog antibody, KH domain containing, RNA binding, signal transduction associated 1b antibody, KHDRBS1 antibody, khdrbs1a antibody, khdrbs1 antibody, Khdrbs1 antibody, khdrbs1.S antibody, khdrbs1b antibody

Background: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:< a href="http://www.uniprot.org/citations/22253824" target="_blank">22253824).

Molecular Weight: 48 kDa

Gene ID: 10657

UniProt: Q07666

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy