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PAX5 antibody (AA 178-207)

PAX5 Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5531798
  • Target See all PAX5 Antibodies
    PAX5 (Paired Box 5 (PAX5))
    Binding Specificity
    • 15
    • 9
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 178-207
    Reactivity
    • 98
    • 47
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 81
    • 15
    • 1
    • 1
    Rabbit
    Clonality
    • 70
    • 28
    Polyclonal
    Conjugate
    • 58
    • 8
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This PAX5 antibody is un-conjugated
    Application
    • 66
    • 47
    • 29
    • 16
    • 15
    • 14
    • 13
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This PAX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 178-207 amino acids from the Central region of human PAX5.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PAX5 Primary Antibody
  • Application Notes
    For WB starting dilution is: 1:1000

    For FACS starting dilution is: 1:10~50

    For IHC-P starting dilution is: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.3 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    PAX5 (Paired Box 5 (PAX5))
    Alternative Name
    PAX5 (PAX5 Products)
    Synonyms
    PAX5 antibody, BSAP antibody, Pax-5 antibody, pax5-a antibody, RGD1565236 antibody, EBB-1 antibody, KLP antibody, Pax[Zf-b] antibody, noi antibody, pax2.1 antibody, pax2a antibody, paxzf-b antibody, paired box 5 antibody, paired box 5 L homeolog antibody, PAX5 antibody, pax5.L antibody, Pax5 antibody, pax5 antibody
    Background
    This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9,14)(p13,q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
    Molecular Weight
    42 kDa
    Gene ID
    5079
    UniProt
    Q02548
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