PKC iota antibody (N-Term)
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- Target See all PKC iota (PRKCI) Antibodies
- PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))
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Binding Specificity
- AA 176-207, N-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PKC iota antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
- Immunogen
- This PKC iota antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-207 amino acids from the N-terminal region of human PKC iota.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product PRKCI Primary Antibody
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- Application Notes
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For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.1 mg/mL
- Buffer
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))
- Alternative Name
- PKC iota (PRKCI Products)
- Synonyms
- DXS1179E antibody, PKCI antibody, nPKC-iota antibody, aPKC[l] antibody, hal antibody, has antibody, PRKCI antibody, PKC antibody, 2310021H13Rik antibody, AI427505 antibody, PKClambda antibody, Pkci antibody, Pkcl antibody, Prkcl antibody, aPKClambda antibody, mKIAA4165 antibody, protein kinase C iota antibody, protein kinase C, iota antibody, PRKCI antibody, prkci antibody, Prkci antibody
- Background
- PKC iota belongs to the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehydes-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis.
- Molecular Weight
- 68 kDa
- Gene ID
- 5584
- UniProt
- P41743
- Pathways
- Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, Tube Formation
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