This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This PLEKHF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-79 amino acids from the N-terminal region of human PLEKHF1.
PLEKHF1
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
Biotin
Application Notes
For WB starting dilution is: 1:1000
Restrictions
For Research Use only
Format
Liquid
Concentration
0.5 mg/mL
Buffer
Supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Target
PLEKHF1
(Pleckstrin Homology Domain Containing, Family F (With FYVE Domain) Member 1 (PLEKHF1))
zgc:63897 antibody, PLEKHF1 antibody, APPD antibody, LAPF antibody, PHAFIN1 antibody, ZFYVE15 antibody, 1810013P09Rik antibody, pleckstrin homology domain containing, family F (with FYVE domain) member 1 antibody, pleckstrin homology and FYVE domain containing 1 antibody, plekhf1 antibody, PLEKHF1 antibody, Plekhf1 antibody
Background
PLEKHF1 may induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.