WISP3 antibody (AA 305-335)

Catalog No. ABIN5532377

Product Details anti-WISP3 Antibody

Target: WISP3 (Wnt1 Inducible Signaling Pathway Protein 3 (WISP3))

Binding Specificity: AA 305-335

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WISP3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This WISP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-335 amino acids from the Central region of human WISP3.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for WISP3

Target: WISP3 (Wnt1 Inducible Signaling Pathway Protein 3 (WISP3))

Alternative Name: WISP3 (WISP3 Products)

Synonyms: CCN6 antibody, LIBC antibody, PPAC antibody, PPD antibody, ENSMUSG00000062074 antibody, Gm735 antibody, WISP-3 antibody, RGD1564120 antibody, WISP3 antibody, si:dkey-119m7.6 antibody, WNT1 inducible signaling pathway protein 3 antibody, WISP3 antibody, Wisp3 antibody, wisp3 antibody

Background: WISP3 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP3 is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of the WISP3 gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis.

Molecular Weight: 39 kDa

Gene ID: 8838

UniProt: O95389

Pathways: WNT Signaling, Growth Factor Binding