PCDHGB4 antibody (AA 353-379)

Catalog No. ABIN5532678

Product Details anti-PCDHGB4 Antibody

Target: PCDHGB4 (Protocadherin gamma Subfamily B, 4 (PCDHGB4))

Binding Specificity: AA 353-379

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHGB4 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PCDHGB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-379 amino acids from the Central region of human PCDHGB4.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.3 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PCDHGB4

Target: PCDHGB4 (Protocadherin gamma Subfamily B, 4 (PCDHGB4))

Alternative Name: PCDHGB4 (PCDHGB4 Products)

Synonyms: CDH20 antibody, FIB2 antibody, PCDH-GAMMA-B4 antibody, protocadherin gamma subfamily B, 4 antibody, PCDHGB4 antibody, Pcdhgb4 antibody

Background: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes.

Molecular Weight: 100 kDa

Gene ID: 8641

UniProt: Q9UN71