MAP3K14 antibody (C-Term)

Catalog No. ABIN5532957

Product Details anti-MAP3K14 Antibody

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Binding Specificity: AA 618-649, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K14 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This NIK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 618-649 amino acids from the C-terminal region of human NIK.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for MAP3K14

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Alternative Name: NIK (MAP3K14 Products)

Synonyms: FTDCR1B antibody, HS antibody, HSNIK antibody, NIK antibody, F23F1.4 antibody, F23F1_4 antibody, mitogen-activated protein kinase kinase kinase 14 antibody, Nik antibody, aly antibody, mitogen-activated protein kinase kinase kinase 14 antibody, MAP3K14 antibody, Map3k14 antibody, MAPKKK14 antibody

Background: HGK, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.

Molecular Weight: 142 kDa

Gene ID: 9448

UniProt: O95819

Pathways: NF-kappaB Signaling, TCR Signaling