ACER1 antibody (C-Term)

Catalog No. ABIN5533348

Product Details anti-ACER1 Antibody

Target: ACER1 (Alkaline Ceramidase 1 (ACER1))

Binding Specificity: AA 236-263, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACER1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ACER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the C-terminal region of human ACER1.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.35 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ACER1

Target: ACER1 (Alkaline Ceramidase 1 (ACER1))

Alternative Name: ACER1 (ACER1 Products)

Synonyms: ASAH3 antibody, asah3 antibody, zgc:110285 antibody, ALKCDase1 antibody, 2310024P18Rik antibody, AI662009 antibody, Alkcdase1 antibody, Asah3 antibody, Cer1 antibody, alkaline ceramidase 1 antibody, ACER1 antibody, acer1 antibody, Acer1 antibody

Background: Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081], Sun et al., 2008 [PubMed 17713573]).

Molecular Weight: 31 kDa

Gene ID: 125981

UniProt: Q8TDN7