This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This ABCC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 625-652 amino acids from the Central region of human ABCC5.
ABCC5
Reactivity: Human
Host: Rabbit
Polyclonal
FITC
Application Notes
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
Restrictions
For Research Use only
Format
Liquid
Concentration
0.5 mg/mL
Buffer
Supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Target
ABCC5
(ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))
ABC33 antibody, EST277145 antibody, MOAT-C antibody, MOATC antibody, MRP5 antibody, SMRP antibody, pABC11 antibody, 2900011L11Rik antibody, AI132311 antibody, Abcc5a antibody, Abcc5b antibody, Mrp5 antibody, abc33 antibody, abcc5 antibody, moat-c antibody, moatc antibody, mrp5 antibody, pabc11 antibody, smrp antibody, ATP binding cassette subfamily C member 5 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 5 antibody, ATP binding cassette subfamily C member 5 L homeolog antibody, ABCC5 antibody, Abcc5 antibody, abcc5.L antibody
Background
ABCC5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs,6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients.