This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This PTPN22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-691 amino acids from the C-terminal region of human PTPN22.
PTPN22
Reactivity: Human
WB
Host: Mouse
Polyclonal
unconjugated
Application Notes
For WB starting dilution is: 1:1000
Restrictions
For Research Use only
Format
Liquid
Concentration
0.5 mg/mL
Buffer
Supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Target
PTPN22
(Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))
70zpep antibody, PEP antibody, Ptpn8 antibody, LYP antibody, LYP1 antibody, LYP2 antibody, PTPN8 antibody, protein tyrosine phosphatase, non-receptor type 22 (lymphoid) antibody, protein tyrosine phosphatase, non-receptor type 22 antibody, Ptpn22 antibody, PTPN22 antibody
Background
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.