NCOR1 antibody (N-Term)

Catalog No. ABIN5534557

Product Details anti-NCOR1 Antibody

Target: NCOR1 (Nuclear Receptor Co-Repressor 1 (NCOR1))

Binding Specificity: AA 16-47, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This NCOR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-47 amino acids from the N-terminal region of human NCOR1.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For IF starting dilution is: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for NCOR1

Target: NCOR1 (Nuclear Receptor Co-Repressor 1 (NCOR1))

Alternative Name: NCOR1 (NCOR1 Products)

Synonyms: ncor antibody, zgc:56355 antibody, 5730405M06Rik antibody, A230020K14Rik antibody, N-CoR antibody, RIP13 antibody, Rxrip13 antibody, mKIAA1047 antibody, N-CoR1 antibody, TRAC1 antibody, hN-CoR antibody, nuclear receptor corepressor 1 antibody, nuclear receptor co-repressor 1 antibody, nuclear receptor corepressor 1 pseudogene antibody, nuclear receptor corepressor 1 S homeolog antibody, ncor1 antibody, NCOR1 antibody, CpipJ_CPIJ002507 antibody, LOC100343278 antibody, Ncor1 antibody, ncor1.S antibody

Background: NCOR1 mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. The gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.

Molecular Weight: 270 kDa

Gene ID: 9611

UniProt: O75376

Pathways: Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process