NDST1 antibody (C-Term)

Catalog No. ABIN5534558

Product Details anti-NDST1 Antibody

Target: NDST1 (N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1 (NDST1))

Binding Specificity: AA 820-849, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NDST1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NDST1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 820-849 amino acids from the C-terminal region of human NDST1.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for NDST1

Target: NDST1 (N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1 (NDST1))

Alternative Name: NDST1 (NDST1 Products)

Synonyms: HSST antibody, NST1 antibody, 1200015G06Rik antibody, Hsst antibody, NDST-1 antibody, fj47c03 antibody, ndst1 antibody, wu:fj47c03 antibody, NDST1 antibody, N-deacetylase and N-sulfotransferase 1 antibody, N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 antibody, N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1b antibody, N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 S homeolog antibody, NDST1 antibody, Ndst1 antibody, ndst1b antibody, ndst1 antibody, ndst1.S antibody

Background: NDST1 is an essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response.

Molecular Weight: 101 kDa

Gene ID: 3340

UniProt: P52848

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Glycosaminoglycan Metabolic Process