XRCC1 antibody (AA 407-435)

Catalog No. ABIN5534833

Product Details anti-XRCC1 Antibody

Target: XRCC1 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1))

Binding Specificity: AA 407-435

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XRCC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This XRCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-435 amino acids from the Central region of human XRCC1.

Isotype: Ig Fraction

Application Details

Application Notes: For IF starting dilution is: 1:25

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For FACS starting dilution is: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for XRCC1

Target: XRCC1 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1))

Alternative Name: XRCC1 (XRCC1 Products)

Synonyms: xrcc1 antibody, MGC80909 antibody, XRCC1 antibody, rcc antibody, RCC antibody, Xrcc-1 antibody, X-ray repair complementing defective repair in Chinese hamster cells 1 antibody, X-ray repair cross complementing 1 antibody, xrcc1 antibody, XRCC1 antibody, Xrcc1 antibody

Background: The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Molecular Weight: 69 kDa

Gene ID: 7515

UniProt: P18887

Pathways: DNA Damage Repair