CHRNA2 antibody (N-Term)

Catalog No. ABIN5535638

Product Details anti-CHRNA2 Antibody

Target: CHRNA2 (Cholinergic Receptor, Nicotinic, alpha 2 (Neuronal) (CHRNA2))

Binding Specificity: AA 42-69, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRNA2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CHRNA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-69 amino acids from the N-terminal region of human CHRNA2.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CHRNA2

Target: CHRNA2 (Cholinergic Receptor, Nicotinic, alpha 2 (Neuronal) (CHRNA2))

Alternative Name: CHRNA2 (CHRNA2 Products)

Synonyms: CHRNA2 antibody, NACHRA2 antibody, chrna2 antibody, zgc:136717 antibody, ACHR antibody, Acra-2 antibody, Acra2 antibody, BC011490 antibody, cholinergic receptor nicotinic alpha 2 subunit antibody, cholinergic receptor, nicotinic, alpha 2a (neuronal) antibody, cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) antibody, neuronal acetylcholine receptor subunit alpha-2 antibody, neuronal acetylcholine receptor subunit alpha-4-like antibody, CHRNA2 antibody, chrna2a antibody, Chrna2 antibody, CpipJ_CPIJ002436 antibody, LOC100370261 antibody, Tsp_10995 antibody

Background: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.

Molecular Weight: 60 kDa

Gene ID: 1135

UniProt: Q15822