BAAT antibody (AA 63-95)

Catalog No. ABIN5535688

Product Details anti-BAAT Antibody

Target: BAAT (Bile Acid CoA: Amino Acid N-Acyltransferase (Glycine N-Choloyltransferase) (BAAT))

Binding Specificity: AA 63-95

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAAT antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BAAT antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 63-95 amino acids from human BAAT.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for BAAT

Target: BAAT (Bile Acid CoA: Amino Acid N-Acyltransferase (Glycine N-Choloyltransferase) (BAAT))

Alternative Name: BAAT (BAAT Products)

Synonyms: BACAT antibody, BAT antibody, AI118337 antibody, AI158864 antibody, kan-1 antibody, BAAT antibody, bile acid-CoA:amino acid N-acyltransferase antibody, Bile acid-CoA:amino acid N-acyltransferase antibody, bile acid-Coenzyme A: amino acid N-acyltransferase antibody, bile acid CoA:amino acid N-acyltransferase antibody, BAAT antibody, RPIC_RS10270 antibody, Bcav_2277 antibody, Rpic12D_1765 antibody, Baat antibody, LOC481635 antibody, LOC100054567 antibody, LOC786798 antibody

Background: Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.

Molecular Weight: 46 kDa

Gene ID: 570

UniProt: Q14032