CHRNG antibody (N-Term)

Catalog No. ABIN5536008

Product Details anti-CHRNG Antibody

Target: CHRNG (Cholinergic Receptor, Nicotinic, gamma (CHRNG))

Binding Specificity: AA 22-50, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRNG antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CHRNG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human CHRNG.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CHRNG

Target: CHRNG (Cholinergic Receptor, Nicotinic, gamma (CHRNG))

Alternative Name: CHRNG (CHRNG Products)

Synonyms: ACHRG antibody, Achr-3 antibody, Acrg antibody, cholinergic receptor nicotinic gamma subunit antibody, cholinergic receptor, nicotinic gamma L homeolog antibody, cholinergic receptor, nicotinic, gamma antibody, cholinergic receptor, nicotinic gamma antibody, cholinergic receptor, nicotinic, gamma polypeptide antibody, CHRNG antibody, chrng.L antibody, Chrng antibody, chrng antibody

Background: The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.

Molecular Weight: 58 kDa

Gene ID: 1146

UniProt: P07510