ERVW-1 antibody (C-Term)

Catalog No. ABIN5536064

Product Details anti-ERVW-1 Antibody

Target: ERVW-1 (Endogenous Retrovirus Group W, Member 1 (ERVW-1))

Binding Specificity: AA 493-521, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERVW-1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ERVWE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-521 amino acids from the C-terminal region of human ERVWE1.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.46 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ERVW-1

Target: ERVW-1 (Endogenous Retrovirus Group W, Member 1 (ERVW-1))

Alternative Name: ERVWE1 (ERVW-1 Products)

Synonyms: ENV antibody, ENVW antibody, ERVWE1 antibody, HERV-7q antibody, HERV-W-ENV antibody, HERV7Q antibody, HERVW antibody, HERVWENV antibody, endogenous retrovirus group W member 1, envelope antibody, ERVW-1 antibody

Background: Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Molecular Weight: 60 kDa

Gene ID: 30816

UniProt: Q9UQF0