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LIN28B antibody (C-Term)

LIN28B Reactivity: Human WB, FACS Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5536363
  • Target See all LIN28B Antibodies
    LIN28B (Lin-28 Homolog B (LIN28B))
    Binding Specificity
    • 11
    • 8
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 218-250, C-Term
    Reactivity
    • 55
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 54
    • 1
    • 1
    Rabbit
    Clonality
    • 53
    • 3
    Polyclonal
    Conjugate
    • 35
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LIN28B antibody is un-conjugated
    Application
    • 41
    • 27
    • 25
    • 23
    • 22
    • 7
    • 6
    • 4
    • 4
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
    Immunogen
    This LIN28B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-250 amino acids from the C-terminal region of human LIN28B.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product LIN28B Primary Antibody
  • Application Notes
    For WB starting dilution is: 1:1000

    For FACS starting dilution is: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    2 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    LIN28B (Lin-28 Homolog B (LIN28B))
    Alternative Name
    LIN28B (LIN28B Products)
    Synonyms
    csdd2 antibody, LIN-28 antibody, CSDD2 antibody, 2810403D23Rik antibody, D030047M17Rik antibody, Lin-28.2 antibody, lin-28 homolog B antibody, lin-28 homolog B S homeolog antibody, lin-28 homolog B (C. elegans) antibody, LIN28B antibody, lin28b antibody, lin28b.S antibody, Lin28b antibody
    Background
    Lin-28 homolog B (LIN28B) is overexpressed in hepatocellular carcinoma. The heterochronic gene lin-28 is a key regulator of developmental timing in the nematode Caenorhabditis elegans. Similar with lin-28 proteins, LIN28B conserves a cold shock domain and a pair of CCHC zinc finger domains. Phylogenetic analysis suggests that they might arise as a result of duplication from an ancestral gene. Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. A short LIN28B isoform was also identified in non-tumor liver tissue and fetal liver. Although predominantly localized in the cytoplasm, LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells. Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation.
    Molecular Weight
    27 kDa
    Gene ID
    389421
    UniProt
    Q6ZN17
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