GNRH1 antibody (N-Term)

Catalog No. ABIN5536391

Product Details anti-GNRH1 Antibody

Target: GNRH1 (Gonadotropin-Releasing Hormone 1 (Luteinizing-Releasing Hormone) (GNRH1))

Binding Specificity: AA 49-77, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNRH1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GNRHR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-77 amino acids from the N-terminal region of human GNRHR.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for GNRH1

Target: GNRH1 (Gonadotropin-Releasing Hormone 1 (Luteinizing-Releasing Hormone) (GNRH1))

Alternative Name: GNRH (GNRH1 Products)

Synonyms: GNRH antibody, GRH antibody, HH12 antibody, LHRH antibody, LNRH antibody, Gnrh antibody, Gnrh2 antibody, Lhrh1 antibody, Lnrh antibody, hpg antibody, Gnrha antibody, Lhrh antibody, Rgnrhg1 antibody, CGNRH-I antibody, GnRH-I antibody, GnRH antibody, gnrh antibody, gnrh1 antibody, grh antibody, lhrh antibody, lnrh antibody, mdGnRH antibody, mdgnrh antibody, mfGnRH antibody, gonadotropin releasing hormone 1 antibody, gonadotropin releasing hormone 1 L homeolog antibody, prepro-gonadotropin-releasing hormone antibody, GNRH1 antibody, Gnrh1 antibody, gnrh1.L antibody, gnrh1 antibody

Background: This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

Molecular Weight: 38 kDa

Gene ID: 2798

UniProt: P30968

Pathways: Hormone Activity