CLCF1 antibody (N-Term)

Catalog No. ABIN5536534

Product Details anti-CLCF1 Antibody

Target: CLCF1 (Cardiotrophin-Like Cytokine Factor 1 (CLCF1))

Binding Specificity: AA 46-72, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLCF1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CLCF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of human CLCF1.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CLCF1

Target: CLCF1 (Cardiotrophin-Like Cytokine Factor 1 (CLCF1))

Alternative Name: CLCF1 (CLCF1 Products)

Synonyms: clc antibody, nr6 antibody, bsf3 antibody, nnt1 antibody, ciss2 antibody, CLCF1 antibody, BSF-3 antibody, BSF3 antibody, CISS2 antibody, CLC antibody, NNT-1 antibody, NNT1 antibody, NR6 antibody, Bsf3 antibody, Clc antibody, cardiotrophin like cytokine factor 1 antibody, cardiotrophin-like cytokine factor 1 antibody, clcf1 antibody, CLCF1 antibody, Clcf1 antibody

Background: This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molecular Weight: 25 kDa

Gene ID: 23529

UniProt: Q9UBD9

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response