This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This RGS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-45 amino acids from the N-terminal region of human RGS1.
RGS1
Reactivity: Human
WB
Host: Mouse
Polyclonal
unconjugated
Application Notes
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
Restrictions
For Research Use only
Format
Liquid
Concentration
0.471 mg/mL
Buffer
Supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1R20 antibody, BL34 antibody, IER1 antibody, IR20 antibody, RGS1 antibody, 1r20 antibody, bl34 antibody, ier1 antibody, ir20 antibody, regulator of G protein signaling 1 antibody, regulator of G-protein signaling 1 antibody, regulator of G-protein signaling 1 S homeolog antibody, Regulator of G-protein signaling 1 antibody, RGS1 antibody, Rgs1 antibody, rgs1.S antibody, rgs1 antibody
Background
RGS1 is a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.