ITM2C antibody (N-Term)
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- Target See all ITM2C Antibodies
- ITM2C (Integral Membrane Protein 2C (ITM2C))
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Binding Specificity
- AA 27-55, N-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ITM2C antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This ITM2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-55 amino acids from the N-terminal region of human ITM2C.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product ITM2C Primary Antibody
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- Application Notes
- For WB starting dilution is: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.36 mg/mL
- Buffer
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- ITM2C (Integral Membrane Protein 2C (ITM2C))
- Alternative Name
- ITM2C (ITM2C Products)
- Synonyms
- 3110038L02Rik antibody, BRI3 antibody, Bricd2c antibody, E25 antibody, E25C antibody, ITM3 antibody, BRICD2C antibody, fj35c02 antibody, itm2c antibody, wu:fj35c02 antibody, zgc:66349 antibody, wu:fj52a04 antibody, zgc:92783 antibody, integral membrane protein 2C antibody, integral membrane protein 2Cb antibody, integral membrane protein 2Ca antibody, Itm2c antibody, ITM2C antibody, itm2cb antibody, itm2ca antibody
- Background
- Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
- Molecular Weight
- 30 kDa
- Gene ID
- 81618
- UniProt
- Q9NQX7
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