RanBP3 antibody (AA 235-445)

Catalog No. ABIN5540645

Product Details anti-RanBP3 Antibody

Target: RanBP3 (RANBP3) (RAN Binding Protein 3 (RANBP3))

Binding Specificity: AA 235-445

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RanBP3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: Recognizes Human RANBP3. Other species not tested.

Purification: Protein-A affinity chromatography

Immunogen: Recombinant human RANBP3 (235-445aa) purified from E. coli.

Clone: AT12E11

Isotype: IgG1

Application Details

Application Notes: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:500.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for RanBP3

Target: RanBP3 (RANBP3) (RAN Binding Protein 3 (RANBP3))

Alternative Name: ranbp3 (RANBP3 Products)

Synonyms: 2610024N24Rik antibody, AA408221 antibody, ranbp3 antibody, MGC79798 antibody, zgc:63485 antibody, RAN binding protein 3 antibody, RAN binding protein 3 L homeolog antibody, RAN binding protein 3a antibody, RANBP3 antibody, Ranbp3 antibody, ranbp3.L antibody, ranbp3 antibody, ranbp3a antibody

Background: The GTPase Ran is a small protein that belongs to the RAS protein superfamily and is found associated with the nuclear membrane. Ran GTPase is essential for mRNA processing, nuclear transport, cell cycle control, mitotic spindle assembly, and postmitotic nuclear re-assembly and nuclear architecture maintenance. Ran binding proteins (RanBPs) belong to a family of proteins that bind Ran GTPase and help to stimulate its GTPase activity. Members of the RanBP family show weak similarity to importin beta, a protein involved in the transport of proteins to the nuclear membrane. Recently it has been shown that RanBP3 function is regulated by the Ras/ERK/RSK and PI3K/Akt signaling pathway. This finding has provided a link between nuclear transport, cell signaling, and cell fate.

UniProt: Q9H6Z4