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HLA-B antibody (AA 241-362)

HLA-B Reactivity: Human WB, ELISA, FACS, IHC, ICC Host: Mouse Monoclonal 2G7B10 unconjugated
Catalog No. ABIN5542338
  • Target See all HLA-B Antibodies
    HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))
    Binding Specificity
    • 11
    • 9
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 241-362
    Reactivity
    • 93
    • 8
    • 8
    • 2
    Human
    Host
    • 64
    • 27
    • 2
    Mouse
    Clonality
    • 68
    • 25
    Monoclonal
    Conjugate
    • 37
    • 15
    • 10
    • 8
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HLA-B antibody is un-conjugated
    Application
    • 53
    • 46
    • 27
    • 17
    • 16
    • 9
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Immunogen
    Purified recombinant fragment of human HLA-B (AA 241-362) expressed in E. Coli.
    Clone
    2G7B10
    Isotype
    IgG1
    Top Product
    Discover our top product HLA-B Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.05 % sodium azide
    Storage
    4 °C,-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Target
    HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))
    Alternative Name
    HLA-B (HLA-B Products)
    Synonyms
    AS antibody, HLAB antibody, SPDA1 antibody, mhc1b antibody, major histocompatibility complex, class I, B antibody, major histocompatibility complex nonclassical class Ib L homeolog antibody, HLA-B antibody, BOLA-B antibody, MAMU-B18 antibody, DKFZP469N1225 antibody, mhc1b.L antibody
    Background
    HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.,
    Molecular Weight
    58.8kDa
    HGNC
    4286
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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