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CRTC1 antibody (AA 19-34)

CRTC1 Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio) WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN401346
  • Target See all CRTC1 Antibodies
    CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))
    Binding Specificity
    • 22
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 19-34
    Reactivity
    • 68
    • 37
    • 25
    • 15
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Zebrafish (Danio rerio)
    Host
    • 56
    • 13
    • 1
    Rabbit
    Clonality
    • 56
    • 14
    Polyclonal
    Conjugate
    • 33
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CRTC1 antibody is un-conjugated
    Application
    • 53
    • 25
    • 20
    • 13
    • 9
    • 8
    • 7
    • 7
    • 6
    • 6
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody is directed against MECT1 protein.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse, Rat, Zebrafish, Pufferfish, Bovine.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Immunogen
    Synthetic peptide corresponding to amino acids 19-34 of human MECT1 protein
    Isotype
    IgG
    Top Product
    Discover our top product CRTC1 Primary Antibody
  • Application Notes
    ELISA: 1/10,000 - 1/40,000. Western Blot: 1/500 - 1/2,000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.95 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
  • Target
    CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))
    Alternative Name
    CRTC1 / MECT1 (CRTC1 Products)
    Synonyms
    MECT1 antibody, TORC-1 antibody, TORC1 antibody, WAMTP1 antibody, AI413414 antibody, Mect1 antibody, R74955 antibody, mKIAA0616 antibody, CRTC1 antibody, crtc1 antibody, fc68c05 antibody, pde4cb antibody, si:ch211-255d18.1 antibody, si:ch211-255d18.8 antibody, wu:fc68c05 antibody, CREB regulated transcription coactivator 1 antibody, CREB regulated transcription coactivator 1b antibody, CRTC1 antibody, Crtc1 antibody, crtc1 antibody, crtc1b antibody
    Background
    MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1, Transducer of regulated cAMP response elementbinding protein 1, TORC1, and Transducer of CREB protein 1) is a nuclear protein that functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11,19) (q21,p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.Synonyms: CREB-regulated transcription coactivator 1, KIAA0616, Mucoepidermoid carcinoma translocated protein 1, TORC1, Transducer of regulated cAMP response element-binding protein 1, WAMTP1
    Gene ID
    23373
    NCBI Accession
    NP_001091952
    UniProt
    Q6UUV9
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