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Tamalin/GRASP antibody (N-Term)

GRASP Reactivity: Mouse, Rat WB, IP, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN401381
  • Target See all Tamalin/GRASP (GRASP) Antibodies
    Tamalin/GRASP (GRASP) (GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP))
    Binding Specificity
    • 4
    • 2
    • 1
    • 1
    N-Term
    Reactivity
    • 17
    • 17
    • 15
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Mouse, Rat
    Host
    • 19
    Rabbit
    Clonality
    • 19
    Polyclonal
    Conjugate
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Tamalin/GRASP antibody is un-conjugated
    Application
    • 10
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)
    Specificity
    This antibody is directed against Tamalin protein.
    Cross-Reactivity (Details)
    Species reactivity (expected):Rat.
    Species reactivity (tested):Mouse.
    Purification
    Affinity chromatography
    Immunogen
    Synthetic peptide corresponding to amino acids near the amino terminus of mouse Tamalin protein
    Isotype
    IgG
    Top Product
    Discover our top product GRASP Primary Antibody
  • Application Notes
    ELISA: 1/4,000 - 1/20,000. Western Blot: 1/500 - 1/3,000. Immunoprecipitation: 1 μg.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.03 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
  • Target
    Tamalin/GRASP (GRASP) (GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP))
    Alternative Name
    GRASP (GRASP Products)
    Synonyms
    GRASP antibody, tamalin antibody, TAMALIN antibody, general receptor for phosphoinositides 1 associated scaffold protein antibody, GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein antibody, GRASP antibody, grasp antibody, Grasp antibody
    Background
    Tamalin, also named General receptor for phosphoinositides 1-associated scaffold protein (GRASP) is a PDZ (post-synaptic density protein/Drosophila disc large tumor suppressor/zo-1) domaincontaining protein that interacts with group 1 metabotropic glutamate receptors (mGluRs). The PDZ domaincontaining amino-terminal half of Tamalin binds directly to the class I PDZ-binding motif of group 1 mGluRs. The carboxyl-terminal half of Tamalin binds to cytohesins, which are guanine nucleotide exchange factors (GEFs) specific for the ADP-ribosylation factor (ARF) family of small GTP-binding proteins. Tamalin forms a protein complex with group 1 mGluRs at the post-synaptic site of specific neuronal cells and serves as a key scaffold protein that links a complex formation between mGluR1a and cytohesins. It is reported that Tamalin plays a key role in the association of group 1 mGluRs with the ARF-specific GEF proteins and contributes to intracellular trafficking and the macromolecular organization of group 1 mGluRs at synapses.Synonyms: GRP1-associated scaffold protein, General receptor for phosphoinositides 1-associated scaffold protein
    Gene ID
    56149
    NCBI Accession
    NP_062391
    UniProt
    Q9JJA9
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