Unc5c antibody (Internal Region)

Catalog No. ABIN452309

Product Details anti-Unc5c Antibody

Target: Unc5c (Unc-5 Homolog C (C. Elegans) (Unc5c))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This Unc5c antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Sequence: NCTVSEEPTG ID

Specificity: This antibody recognizes UNC5C.

Cross-Reactivity (Details): Species reactivity (expected):Human, Canine.
Species reactivity (tested):Mouse.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence NCTVSEEPTGID, from the internal region of the protein sequence . Genename: UNC5C

Application Details

Application Notes: Peptide ELISA: 1/32000. Immunofluorescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for Unc5c

Target: Unc5c (Unc-5 Homolog C (C. Elegans) (Unc5c))

Alternative Name: UNC5C (Unc5c Products)

Synonyms: UNC5C antibody, UNC5H3 antibody, 6030473H24 antibody, AI047720 antibody, B130051O18Rik antibody, Unc5h3 antibody, rcm antibody, wu:fb03d07 antibody, unc-5 netrin receptor C antibody, UNC5C antibody, Unc5c antibody, unc5c antibody

Background: UNC5C is a receptor for netrin required for axon guidance. It mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It is also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. There are two named isoforms.Synonyms: Netrin receptor UNC5C, Protein unc-5 homolog C, UNC5H3, Unc-5 homolog 3

Gene ID: 8633

NCBI Accession: NP_003719

UniProt: O95185