UCP2
Reactivity: Human, Mouse, Rat
WB, ICC, IF
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Peptide ELISA: 1/4000. Western Blot: 0.2 - 1 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Format
Liquid
Concentration
0.5 mg/mL
Buffer
Tris buffered saline, pH~7.3 0.02% Sodium Azide 0.5% BSA
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date
12 months
Liu, Shim, Nguyen, Gibbons, Mitchell, Poirier: "Tempol protects cardiomyocytes from nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 139, Issue 1, pp. 133-41, (2014) (PubMed).
Target
UCP2
(Uncoupling Protein 2 (Mitochondrial, Proton Carrier) (UCP2))
UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP2 gene is expressed in many tissues, with the greatest expression in skeletal muscle. UCP2 is thought to play a role in non shivering thermogenesis, obesity and diabetes. Alternate names: Mitochondrial uncoupling protein 2, Solute carrier family 25 member 8, UCP 2, UCP-2, UCPH