CNTF Receptor alpha antibody (Internal Region)

Catalog No. ABIN375185

Product Details anti-CNTF Receptor alpha Antibody

Target: CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))

Binding Specificity: Internal Region

Reactivity: Mouse

Host: Goat

Clonality: Polyclonal

Conjugate: This CNTF Receptor alpha antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to CNTFR.

Cross-Reactivity (Details): Species reactivity (expected):Human, Rat, Canine.
Species reactivity (tested):Mouse.

Purification: Affinity chromatography

Immunogen: Peptide with sequence CRSNTYPKGFY, from the internal region of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/16000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CNTF Receptor alpha

Target: CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))

Alternative Name: CNTFR (CNTFR Products)

Synonyms: CNTFR-alpha antibody, CNTFRALPHA antibody, Cntfralpha antibody, cb549 antibody, fj33e02 antibody, sb:cb549 antibody, wu:fj33e02 antibody, si:bz76a6.1 antibody, si:dz248f2.1 antibody, si:rp71-76a6.1 antibody, ciliary neurotrophic factor receptor antibody, ciliary neurotrophic factor receptor L homeolog antibody, CNTFR antibody, cntfr.L antibody, Cntfr antibody, cntfr antibody

Background: CNTF Receptor alpha is a receptor belonging to the cytokine superfamily of receptors. Along with LIFR and gp130, CNTF Receptor alpha forms the heterotrimeric CNTF receptor complex. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. During signal transduction, CNTF first binds to CNTF Recepror alpha, and this permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.Synonyms: CNTFR, CNTFR alpha, Ciliary neurotrophic factor receptor alpha

Gene ID: 12804

NCBI Accession: NP_001129528

UniProt: O88507

Pathways: JAK-STAT Signaling, Feeding Behaviour