SNAP23 antibody (C-Term)

Catalog No. ABIN569620

Product Details anti-SNAP23 Antibody

Target: SNAP23 (Synaptosomal-Associated Protein, 23kDa (SNAP23))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This SNAP23 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-TDKADTNRDR

Specificity: This antibody is expected to recognize both isoforms (NP_003816.2, NP_570710.1). Amino acid numbering in name refers to NP_003816.2 sequence.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Dog, Cow, Rabbit.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_003816.2, NP_570710.1. Genename: SNAP23

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SNAP23

Target: SNAP23 (Synaptosomal-Associated Protein, 23kDa (SNAP23))

Alternative Name: SNAP23 (SNAP23 Products)

Synonyms: 23kDa antibody, AA408749 antibody, SNAP-23 antibody, Sndt antibody, Syndet antibody, HsT17016 antibody, SNAP23A antibody, SNAP23B antibody, XOSNAP-23 antibody, snap23-A antibody, synaptosome associated protein 23 antibody, synaptosome associated protein 23kDa antibody, synaptosomal-associated protein 23 antibody, synaptosome associated protein 23kDa L homeolog antibody, SNAP23 antibody, snap23 antibody, Snap23 antibody, snap23.L antibody

Background: Synaptosomal-associated proteins (SNAPs) are cytosolic proteins that play a key role in in the process of membrane fusion in intracellular vesicle trafficking. In eukaryotic cells, the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex is critical to membrane docking and fusion and is believed to impart some degree of specificity between vesicle SNARE (v-SNARE) and target organelle SNARE (t-SNARE). In neurons and neuroendocrine cells, the SNARE complex consists of the integral membrane proteins VAMP (vesicle-associated membrane protein), syntaxin and SNAP-25. In non-neuronal tissue, a SNAP-25 homolog, SNAP-23, functionally replaces SNAP-25 in the SNARE complex. Studies show that VAMP, syntaxin and SNAP-23 are required for SNARE function and that this complex exists as a heterotrimer of the three proteins. In insulin signalling pathways, studies suggest that the translocation of GLUT4 in adipocytes requires that functional SNAP-23 be present in SNARE complexes.Synonyms: SNAP-23, Synaptosomal-associated protein 23, Vesicle-membrane fusion protein SNAP-23

Gene ID: 8773

NCBI Accession: NP_003816

UniProt: O00161