SIK2 antibody (Center)

Catalog No. ABIN783466

Product Details anti-SIK2 Antibody

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIK2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects SIK2 at Center. SIK2 antibody is predicted to not cross-react with other SIK protein family members.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the center of human SIK2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for SIK2

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Alternative Name: SIK2 (SIK2 Products)

Synonyms: PIG33 antibody, SC1 antibody, LOH11CR1I antibody, QIK antibody, SNF1LK2 antibody, G630080D20Rik antibody, Snf1lk2 antibody, RGD1559698 antibody, si:dkey-27p23.1 antibody, snf1lk2a antibody, SPARC like 1 antibody, salt inducible kinase 2 antibody, salt-inducible kinase 2 antibody, salt-inducible kinase 2a antibody, SPARCL1 antibody, SIK2 antibody, SLK2 antibody, Sik2 antibody, sik2a antibody

Background: Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1?alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.Synonyms: QIK, Qin-induced kinase, SIK-2, SNF1LK2, Salt-inducible protein kinase 2, Serine/threonine-protein kinase SIK2, Serine/threonine-protein kinase SNF1-like kinase 2

Gene ID: 23235

NCBI Accession: NP_056006

UniProt: Q9H0K1