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TMC6 antibody (N-Term)

TMC6 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499806
  • Target See all TMC6 Antibodies
    TMC6 (Transmembrane Channel-Like 6 (TMC6))
    Binding Specificity
    • 8
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Human, Mouse, Rat
    Host
    • 16
    Rabbit
    Clonality
    • 16
    Polyclonal
    Conjugate
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    This TMC6 antibody is un-conjugated
    Application
    • 16
    • 13
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to EVER1.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    EVER1 antibody was raised against a 14 amino acid peptide from near the amino terminus of human EVER1.
    Isotype
    IgG
  • Application Notes
    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    TMC6 (Transmembrane Channel-Like 6 (TMC6))
    Alternative Name
    TMC6 / EVER1 (TMC6 Products)
    Synonyms
    EVER1 antibody, zgc:92610 antibody, MGC83549 antibody, ever1 antibody, EV1 antibody, EVIN1 antibody, LAK-4P antibody, D11Ertd204e antibody, transmembrane channel like 6 antibody, transmembrane channel-like 6b antibody, transmembrane channel like 6 L homeolog antibody, transmembrane channel-like gene family 6 antibody, TMC6 antibody, tmc6b antibody, tmc6.L antibody, tmc6 antibody, Tmc6 antibody
    Background
    Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance. At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.Synonyms: EVIN1, Epidermodysplasia verruciformis protein 1, LAK-4, Transmembrane channel-like protein 6
    Gene ID
    11322
    UniProt
    Q7Z403
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