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IRGM antibody (N-Term)

IRGM Reactivity: Human, Mouse, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500068
  • Target See all IRGM Antibodies
    IRGM (Immunity-Related GTPase Family, M (IRGM))
    Binding Specificity
    • 15
    • 12
    • 9
    • 7
    • 6
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Human, Mouse, Rat
    Host
    • 42
    • 4
    Rabbit
    Clonality
    • 42
    • 4
    Polyclonal
    Conjugate
    • 12
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IRGM antibody is un-conjugated
    Application
    • 45
    • 23
    • 19
    • 13
    • 13
    • 12
    • 11
    • 5
    • 3
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects IRGM at N-term.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    IRGM antibody was raised against a 17 amino acid peptide near the amino terminus of the human IRGM.
    Isotype
    IgG
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    Discover our top product IRGM Primary Antibody
  • Application Notes
    ELISA. Western blot: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    IRGM (Immunity-Related GTPase Family, M (IRGM))
    Alternative Name
    IRGM / LRG-47 (IRGM Products)
    Synonyms
    Ifi1 antibody, Iigp3 antibody, Iipg3 antibody, Irgm antibody, LRG-47 antibody, IFI1 antibody, IRGM1 antibody, LRG47 antibody, immunity-related GTPase family M member 1 antibody, immunity-related GTPase M antibody, immunity related GTPase M antibody, immunity-related GTPase family M protein antibody, Irgm1 antibody, Irgm antibody, IRGM antibody, LOC481473 antibody
    Background
    Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.Synonyms: IFI1, IRGM1, Immunity-related GTPase family M protein, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LRG47
    Gene ID
    345611
    UniProt
    F8VPC9
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