ORAI2 antibody (C-Term)

Catalog No. ABIN500423

Product Details anti-ORAI2 Antibody

Target: ORAI2 (ORAI Calcium Release-Activated Calcium Modulator 2 (ORAI2))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORAI2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody detects ORAI2 at C-term. It is predicted to have no cross-reactivity to ORAI1 or ORAI3.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogen: ORAI2 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human ORAI2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for ORAI2

Target: ORAI2 (ORAI Calcium Release-Activated Calcium Modulator 2 (ORAI2))

Alternative Name: ORAI2 (ORAI2 Products)

Synonyms: C7orf19 antibody, CBCIP2 antibody, MEM142B antibody, TMEM142B antibody, A730041O15Rik antibody, Tmem142b antibody, RGD1310213 antibody, ORAI2 antibody, orai-1 antibody, orai1 antibody, tmem142a antibody, tmem142b antibody, LOC100230993 antibody, ORAI calcium release-activated calcium modulator 2 antibody, ORAI calcium release-activated calcium modulator 2 S homeolog antibody, ORAI2 antibody, Orai2 antibody, orai2.S antibody, orai2 antibody

Background: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI2 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. Like ORAI1, ORAI2 has been shown to function as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor, although at a lesser efficacy than ORAI1.Synonyms: C7orf19, CAP-binding protein complex-interacting protein 2, CBCIP2, Protein orai-2, TMEM142B, Transmembrane protein 142B

Gene ID: 80228

UniProt: Q96SN7