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PPAPDC2 antibody (C-Term)

PPAPDC2 Reactivity: Human, Mouse, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500531
  • Target See all PPAPDC2 Antibodies
    PPAPDC2 (Phosphatidic Acid Phosphatase Type 2 Domain Containing 2 (PPAPDC2))
    Binding Specificity
    • 14
    • 9
    • 2
    • 1
    • 1
    C-Term
    Reactivity
    • 20
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 20
    Rabbit
    Clonality
    • 20
    Polyclonal
    Conjugate
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    This PPAPDC2 antibody is un-conjugated
    Application
    • 20
    • 14
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    PPAPDC2 antibody was raised against a 13 amino acid peptide from near the carboxy terminus human PPAPDC2.
    Isotype
    IgG
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  • Application Notes
    ELISA. Western blot: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody (in aliquots) at -20 °C.
  • Pant, Kocarek: "Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 44, Issue 3, pp. 352-5, (2016) (PubMed).

  • Target
    PPAPDC2 (Phosphatidic Acid Phosphatase Type 2 Domain Containing 2 (PPAPDC2))
    Alternative Name
    PPAPDC2 (PPAPDC2 Products)
    Synonyms
    PPAPDC2 antibody, PDP1 antibody, PSDP antibody, bA6J24.6 antibody, 4932443D16Rik antibody, phospholipid phosphatase 6 antibody, PLPP6 antibody, plpp6 antibody, Plpp6 antibody
    Background
    PPAPDC2 is a phosphatase that dephosphorylates Presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may have important role in innate immunity. PSDP is a bioactive lipid that rapidly remodels to PSMP upon cell activation. PPAPDC2 displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and has been identified in activated human neutrophil (PMN) extracts. It is widely expressed in human tissues. Recent studies shows PPAPDC2 is a functional isoprenoid diphosphate phosphatase.Synonyms: PPAP2 domain-containing protein 2, Phosphatidic acid phosphatase type 2 domain-containing protein 2, Presqualene diphosphate phosphatase
    Gene ID
    403313
    NCBI Accession
    NP_982278
    UniProt
    Q8IY26
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