SPRED2 antibody (Center)

Catalog No. ABIN500800

Product Details anti-SPRED2 Antibody

Target: SPRED2 (Sprouty-Related, EVH1 Domain Containing 2 (SPRED2))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPRED2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects SPRED2. It is predicted to have no cross-reactivity to Spred1 or Spred3.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogen: Spred2 antibody was raised against a 13 amino acid peptide near the center of the human Spred2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for SPRED2

Target: SPRED2 (Sprouty-Related, EVH1 Domain Containing 2 (SPRED2))

Alternative Name: SPRED2 (SPRED2 Products)

Synonyms: SPRED2 antibody, Xspred2 antibody, spred-2 antibody, Xtspred2 antibody, spred2 antibody, wu:fb93f08 antibody, zgc:77284 antibody, Spred-2 antibody, C79158 antibody, sprouty related EVH1 domain containing 2 antibody, sprouty related, EVH1 domain containing 2 antibody, sprouty-related, EVH1 domain containing 2b antibody, sprouty-related, EVH1 domain containing 2 antibody, SPRED2 antibody, spred2 antibody, spred2b antibody, Spred2 antibody

Background: Spred2 is a member of the Sprouty family, a group of proteins that act as negative regulators during development. Like Spred1, Spred2 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. At least two isoforms of Spred2 are known to exist.Synonyms: MGC163164, Spred-2, Sprouty-related EVH1 domain containing 2

Gene ID: 200734

NCBI Accession: NP_861449