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USP6 antibody (C-Term)

USP6 Reactivity: Human WB, EIA Host: Goat Polyclonal unconjugated
Catalog No. ABIN784289
  • Target See all USP6 Antibodies
    USP6 (Ubiquitin Specific Peptidase 6 (USP6))
    Binding Specificity
    • 15
    • 7
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 34
    • 11
    • 9
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 30
    • 2
    • 2
    Goat
    Clonality
    • 32
    • 2
    Polyclonal
    Conjugate
    • 13
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This USP6 antibody is un-conjugated
    Application
    • 22
    • 16
    • 8
    • 8
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Sequence
    KISPLHHLQM ECSP
    Specificity
    This antibody recognizes USP6/TRE2/TRE17
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
    Immunogen
    Peptide with sequence from the C Terminus of the protein sequence according to NP_004496.1. Genename: USP6
    Top Product
    Discover our top product USP6 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    USP6 (Ubiquitin Specific Peptidase 6 (USP6))
    Alternative Name
    USP6 / TRE2 (USP6 Products)
    Synonyms
    HRP1 antibody, TRE2 antibody, TRE17 antibody, Tre-2 antibody, USP6-short antibody, ubiquitin specific peptidase 6 antibody, ubiquitin carboxyl-terminal hydrolase 6 antibody, Ubiquitin carboxyl-terminal hydrolase 6, putative antibody, USP6 antibody, CNG04540 antibody, ANI_1_2152104 antibody, AOR_1_208094 antibody, MCYG_00569 antibody, CC1G_15273 antibody, MGYG_01395 antibody, CGB_G0160W antibody, LOC100282385 antibody
    Background
    Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16,17)(q22,p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.Synonyms: Deubiquitinating enzyme 6, HRP1, TRE-2, Ubiquitin carboxyl-terminal hydrolase 6, Ubiquitin thioesterase 6, Ubiquitin-specific-processing protease 6
    Gene ID
    9098
    NCBI Accession
    NP_004496
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