TLE3 antibody (N-Term)

Catalog No. ABIN1109265

Product Details anti-TLE3 Antibody

Target: TLE3 (Transducin-Like Enhancer Protein 3 (TLE3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLE3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GSSSGLLALG ALGSQAHLTV KDEKNHHELD HRERESSANN SVSPSESLRA

Cross-Reactivity (Details): Species reactivity (expected):Dog, Mouse, Rat, ZebrafishSpecies reactivity (tested):Human

Purification: Purified using Protein A affinity column

Immunogen: The immunogen for anti-TLE3 antibody: synthetic peptide directed towards the N terminal of human TLE3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 100 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for TLE3

Target: TLE3 (Transducin-Like Enhancer Protein 3 (TLE3))

Alternative Name: TLE3 (TLE3 Products)

Synonyms: TLE3 antibody, ESG antibody, ESG1 antibody, Xesg1 antibody, esg2 antibody, esg3 antibody, grg2 antibody, grg3 antibody, hst18976 antibody, tle3 antibody, xgrg3 antibody, ESG3 antibody, GRG3 antibody, HsT18976 antibody, Esp3 antibody, 2610103N05Rik antibody, Grg3a antibody, Grg3b antibody, mKIAA1547 antibody, transducin like enhancer of split 3 antibody, transducin like enhancer of split 2 antibody, transducin-like enhancer of split 3 antibody, TLE3 antibody, tle2 antibody, Tle3 antibody

Background: The TLE genes are differentially expressed and encode nuclear proteins, consistent with the presence of sequence motifs associated with nuclear functions. These genes are the human homologues of Drosophila groucho, a member of the Notch signaling pathway which controls a number of different cell-fate choices in invertebrates and vertebrates.TLE3 is a transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.Synonyms: ESG3, GRG3, KIAA1547, Transducin-like enhancer protein 3

Gene ID: 7090

NCBI Accession: NP_005069

Pathways: SARS-CoV-2 Protein Interactome