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CARD10 antibody (N-Term)

CARD10 Reactivity: Human IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1449965
  • Target See all CARD10 Antibodies
    CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))
    Binding Specificity
    • 7
    • 7
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 34
    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 34
    Rabbit
    Clonality
    • 34
    Polyclonal
    Conjugate
    • 17
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CARD10 antibody is un-conjugated
    Application
    • 24
    • 19
    • 7
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    16 amino acid synthetic peptide near the amino terminus of human CARMA3
    Isotype
    IgG
    Top Product
    Discover our top product CARD10 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))
    Alternative Name
    CARD10 / CARMA3 (CARD10 Products)
    Synonyms
    CARD10 antibody, BIMP1 antibody, CARMA3 antibody, AI449026 antibody, Bimp1 antibody, Carma3 antibody, caspase recruitment domain family, member 10 antibody, caspase recruitment domain family member 10 antibody, Card10 antibody, CARD10 antibody
    Background
    CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein binds to BCL10 and activates NF-kB Recent experiments have shown that CARMA3 is required for EGF-induced NF-kB activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.Synonyms: BIMP1, CARD10, Caspase recruitment domain family member 10
    Gene ID
    29775
    NCBI Accession
    NP_055365
    Pathways
    S100 Proteins
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