SPINK2 antibody (C-Term)

Catalog No. ABIN1450114

Product Details anti-SPINK2 Antibody

Target: SPINK2 (serine Peptidase Inhibitor, Kazal Type 2 (Acrosin-Trypsin Inhibitor) (SPINK2))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPINK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid synthetic peptide near the carboxy terminus of Human SPINK2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-SPINK2 antibody (ABIN1450114)

Dietz, Maes, Huang, Yandell, Schlamp, Montgomery, Allingham, Hauser, Nickells: "Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage." in: PLoS ONE, Vol. 9, Issue 4, pp. e93564, (2014) (PubMed).

Target Details for SPINK2

Target: SPINK2 (serine Peptidase Inhibitor, Kazal Type 2 (Acrosin-Trypsin Inhibitor) (SPINK2))

Alternative Name: SPINK2 (SPINK2 Products)

Synonyms: 1700007F22Rik antibody, AV038945 antibody, HUSI-II antibody, serine peptidase inhibitor, Kazal type 2 antibody, serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) antibody, Spink2 antibody, SPINK2 antibody

Background: Human serine proteinase inhibitor Kazal-type 2 (SPINK2) is required for maintaining normal spermatogenesis and potentially regulates serine protease-mediated apoptosis in male germ cells. It contains a typical kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. SPINK2 plays a role in the pathogenesis of hereditary and chronic pancreatitis.Synonyms: Acrosin-trypsin inhibitor, HUSI-II, Serine protease inhibitor Kazal-type 2

Gene ID: 6691

NCBI Accession: NP_065804