TLR6 antibody (AA 280-512) (FITC)

Catalog No. ABIN5564273

Product Details anti-TLR6 Antibody (FITC)

Target: TLR6 (Toll-Like Receptor 6 (TLR6))

Binding Specificity: AA 280-512

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TLR6 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Specificity: Recognizes human TLR6.

Cross-Reactivity: Human

Purification: Protein G purified.

Immunogen: Recombinant human TLR6 protein (aa 280-512).

Clone: ABM1B50

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In 10 mM TRIS containing 150 mM NaCl and 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: +4°C
Stable for at least 6 months after receipt when stored at +4°C.

Expiry Date: 6 months

Target Details for TLR6

Target: TLR6 (Toll-Like Receptor 6 (TLR6))

Alternative Name: TLR6 (TLR6 Products)

Synonyms: TLR1 antibody, TLR16 antibody, CD286 antibody, TLR-6 antibody, toll-like receptor 1 family member A antibody, toll like receptor 6 antibody, toll-like receptor 6 antibody, TLR1A antibody, TLR6 antibody, Tlr6 antibody

Background: TLR6 (Toll-like Receptor 6) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR6 in complex with TLR2 specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides from Gram-positive bacteria and fungi. The activation cluster TLR2:TLR6:CD14:CD36 signals via MYD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. In complex with TLR2 recognizes MALP-2, STF, PSM and OspA-L, as well. In response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, TLR6 forms a heterodimer with TLR4. This complex rapidly internalizes and triggers inflammatory responses through the NF-kappaB-dependent MYD88 signaling or via TICAM1 signaling pathways. The complex promotes sterile inflammation in monocytes/macrophages. TLR6 has emerged as the most potent activator for ZNPs (Zinc Oxide Nanoparticles)-induced inflammatory responses. Various polymorphism have been associated with inflammatory and tumor pathologies.

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades