CYGB antibody

Catalog No. ABIN5647305

Product Details anti-CYGB Antibody

Target: CYGB (Cytoglobin (CYGB))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYGB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogen: Amino acids M1-P190 from the human protein were used as the immunogen for the Cytoglobin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Cytoglobin antibody should be determined by the researcher.\. WB: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Cytoglobin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for CYGB

Target: CYGB (Cytoglobin (CYGB))

Alternative Name: Cytoglobin (CYGB Products)

Synonyms: cygb antibody, wu:fb77d07 antibody, wu:fb93a03 antibody, zgc:109806 antibody, MGC89562 antibody, CYGB antibody, cygb-1 antibody, MGC84306 antibody, 3110001K20Rik antibody, HGb antibody, Staap antibody, HGB antibody, STAP antibody, Stap antibody, cytoglobin 1 antibody, cytoglobin antibody, cytoglobin-1 antibody, cytoglobin L homeolog antibody, cygb1 antibody, cygb antibody, CYGB antibody, cygb.L antibody, Cygb antibody

Background: Cytoglobin (CYGB), also called HGB or STAP, is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress. The cytoglobin gene is mapped on 17q25.1. The CYGB gene contains 4 exons and spans about 9 kb. Cytoglobin has many elements common to vertebrate globins, including invariant histidine residues, and the amino acids that form the heme pocket share similarity with pentacoordinate myoglobin. In contrast to the high oxygen affinities displayed by most hexacoordinate hemoglobins, the characteristics of CYGB indicate that it can facilitate oxygen transport. Because the oxygen affinity of CYGB is more similar to myoglobin than to neuroglobin, and the oxy form of CYGB resists autooxidation, CYGB is proposed to represent a tissue oxygen reservoir.

UniProt: Q8WWM9