NCR3 antibody (AA 31-65)

Catalog No. ABIN5647395

Product Details anti-NCR3 Antibody

Target: NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))

Binding Specificity: AA 31-65

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCR3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 31-65 from the N-terminal region of the human protein was used as the immunogen for the NKp30 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the NKp30 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western Blot: 1:1000

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the NKp30 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for NCR3

Target: NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))

Alternative Name: NKp30 / NCR3 (NCR3 Products)

Synonyms: MGC133750 antibody, 1C7 antibody, CD337 antibody, LY117 antibody, MALS antibody, NKp30 antibody, Nkp30 antibody, natural cytotoxicity triggering receptor 3 antibody, NCR3 antibody, Ncr3 antibody

Background: Natural cytotoxicity triggering receptor 3 (NCR3), also called Natural killer cell p30-related protein (NKp30), is a cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.

UniProt: O14931

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process