COPS7B antibody (AA 223-257)

Catalog No. ABIN5647523

Product Details anti-COPS7B Antibody

Target: COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))

Binding Specificity: AA 223-257

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS7B antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity (Details): Expected species reactivity: Bovine

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 223-257 from the human protein was used as the immunogen for the COPS7B antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Western blot: 1:500-1:1000

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the COPS7B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for COPS7B

Target: COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))

Alternative Name: COPS7B / CSN7b (COPS7B Products)

Synonyms: MGC114836 antibody, D1Wsu66e antibody, E130114M23 antibody, CSN7B antibody, COP9 signalosome subunit 7B antibody, COP9 signalosome subunit 7B S homeolog antibody, Cops7b antibody, COPS7B antibody, cops7b.S antibody

Background: COP9 signalosome complex subunit 7b is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene ID: 64708

UniProt: Q9H9Q2

Pathways: Cell Division Cycle