Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

CTCFL antibody (AA 617-650)

CTCFL Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5647666
  • Target See all CTCFL Antibodies
    CTCFL (CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL))
    Binding Specificity
    • 15
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 617-650
    Reactivity
    • 28
    • 11
    • 3
    Human
    Host
    • 31
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 32
    • 2
    Polyclonal
    Conjugate
    • 16
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CTCFL antibody is un-conjugated
    Application
    • 28
    • 13
    • 13
    • 12
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 617-650 from the human protein was used as the immunogen for the CTCFL antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CTCFL Primary Antibody
  • Application Notes
    Western blot: 1:1000-2000
    Restrictions
    For Research Use only
  • Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the CTCFL antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    CTCFL (CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL))
    Alternative Name
    CTCFL / BORIS (CTCFL Products)
    Synonyms
    BORIS antibody, CT27 antibody, CTCF-T antibody, HMGB1L1 antibody, dJ579F20.2 antibody, CTCFL antibody, Boris antibody, OTTMUSG00000016680 antibody, CCCTC-binding factor like antibody, CCCTC-binding factor (zinc finger protein)-like antibody, CTCFL antibody, Ctcfl antibody
    Background
    Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
    Gene ID
    140690
    UniProt
    Q8NI51
You are here:
Support