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RAN antibody

RAN Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5647982
  • Target See all RAN Antibodies
    RAN (RAN, Member RAS Oncogene Family (RAN))
    Reactivity
    • 88
    • 44
    • 42
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 81
    • 5
    • 2
    Rabbit
    Clonality
    • 82
    • 5
    Polyclonal
    Conjugate
    • 43
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This RAN antibody is un-conjugated
    Application
    • 65
    • 34
    • 28
    • 26
    • 26
    • 17
    • 11
    • 10
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    Antigen affinity purified
    Immunogen
    A recombinant human protein corresponding to amino acids A2-L216 was used as the immunogen for the RAN antibody.
    Isotype
    IgG
    Top Product
    Discover our top product RAN Primary Antibody
  • Application Notes
    Optimal dilution of the RAN antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the RAN antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    RAN (RAN, Member RAS Oncogene Family (RAN))
    Alternative Name
    RAN / Ras-related nuclear protein (RAN Products)
    Synonyms
    ARA24 antibody, Gsp1 antibody, TC4 antibody, ran antibody, ara24 antibody, gsp1 antibody, ran-1 antibody, tc4 antibody, RAN antibody, RANP1 antibody, AAF30287 antibody, CG1404 antibody, Dmel\CG1404 antibody, Ran antibody, dran antibody, l(1)G0075 antibody, ran10A antibody, fc16b04 antibody, wu:fc16b04 antibody, RAN, member RAS oncogene family antibody, RAN, member RAS oncogene family S homeolog antibody, CG1404 gene product from transcript CG1404-RC antibody, RAN antibody, Ran antibody, ran.S antibody, ran antibody
    Background
    RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
    UniProt
    P62826
    Pathways
    Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus
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