RACGAP1 antibody (AA 1-110)

Catalog No. ABIN565414

Product Details anti-RACGAP1 Antibody

Target: RACGAP1 (Rac GTPase Activating Protein 1 (RACGAP1))

Binding Specificity: AA 1-110

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RACGAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Mouse monoclonal antibody raised against a partial recombinant RACGAP1.

Sequence: MDTMMLNVRN LFEQLVRRVE ILSEGNEVQF IQLAKDFEDF RKKWQRTDHE LGKYKDLLMK AETERSALDV KLKHARNQVD VEIKRRQRAE ADCEKLERQI QLIREMLMCD

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: RACGAP1 (AAH32754, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 1G6

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-RACGAP1 antibody (ABIN565414)

Lekomtsev, Su, Pye, Blight, Sundaramoorthy, Takaki, Collinson, Cherepanov, Divecha, Petronczki: "Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis." in: Nature, Vol. 492, Issue 7428, pp. 276-9, (2012) (PubMed).

Wang, Ooi, Hui: "Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 18, pp. 6040-51, (2011) (PubMed).

Wolfe, Takaki, Petronczki, Glotzer: "Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation." in: PLoS biology, Vol. 7, Issue 5, pp. e1000110, (2009) (PubMed).

Burkard, Maciejowski, Rodriguez-Bravo, Repka, Lowery, Clauser, Zhang, Shokat, Carr, Yaffe, Jallepalli: "Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells." in: PLoS biology, Vol. 7, Issue 5, pp. e1000111, (2009) (PubMed).

Target Details for RACGAP1

Target: RACGAP1 (Rac GTPase Activating Protein 1 (RACGAP1))

Alternative Name: RACGAP1 (RACGAP1 Products)

Synonyms: CYK4 antibody, HsCYK-4 antibody, ID-GAP antibody, MgcRacGAP antibody, cyk-4 antibody, id-gap antibody, mgcracgap antibody, RACGAP1 antibody, MGC121578 antibody, Gap antibody, RasGAP antibody, Rasa antibody, GAPX antibody, AI227039 antibody, AI327394 antibody, Band25 antibody, GTPase antibody, gtl11 antibody, mKIAA1478 antibody, wu:fb92c08 antibody, zgc:77839 antibody, Rac GTPase activating protein 1 antibody, rac GTPase-activating protein 1 antibody, Rac GTPase activating protein 1 L homeolog antibody, RAS p21 protein activator 1 antibody, Rac GTPase-activating protein 1 antibody, si:ch1073-416j23.1 antibody, RACGAP1 antibody, racgap1 antibody, racgap1.L antibody, racgap1.2.L antibody, racgap1.2 antibody, Rasa1 antibody, Racgap1 antibody, si:ch1073-416j23.1 antibody

Background: Full Gene Name: Rac GTPase activating protein 1
Synonyms: HsCYK-4,ID-GAP,MgcRacGAP

Gene ID: 29127

Pathways: Regulation of Actin Filament Polymerization, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling of Hepatocyte Growth Factor Receptor